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The primary challenge was the extreme rarity of PNECs, which make up less than 1% of lung cells, making them nearly impossible to isolate and study in depth, Zhang said

Brill also questioned how well Imperial will be able to compete against its bigger rivals, given that it is buying some of Reynolds weak and declining brands

Lisa Surtees, Acting Director of Fresh, said: Most roll-up smokers are price conscious, and we have seen an increase since the start of the recession